Career Development Award - Clinical

Circulating RNA coding genes regulating apoptosis in maternal blood in severe early onset fetal growth restriction and pre-eclampsia

CL Whitehead, SP Walker, M Lappas, S Tong

2013-08-01

Objective:To determine whether the intrinsic apoptosis pathway is differentially expressed in placenta and maternal blood in sever..

The use of miRNA microarrays for the analysis of cancer samples with global miRNA decrease

D Wu, Y Hu, S Tong, BRG Williams, GK Smyth, MP Gantier

2013-07-01

Recent studies have established that mutations or deletions in microRNA (miRNA) processing enzymes resulting in a global decrease ..

MT-MMPs in pre-eclamptic placenta: Relationship to soluble endoglin production

TJ Kaitu'u-Lino, L Tuohey, L Ye, K Palmer, M Skubisz, S Tong

2013-02-01

Introduction: Pre-eclampsia is a serious complication of pregnancy, characterized by severe endothelial dysfunction resulting in h..

Targeted nanoparticle delivery of doxorubicin into placental tissues to treat ectopic pregnancies

TJ Kaitu'u-Lino, S Pattison, L Ye, L Tuohey, P Sluka, J MacDiarmid, H Brahmbhatt, T Johns, AW Horne, J Brown, S Tong

2013-02-01

Abnormal trophoblast growth can cause life-threatening disorders such as ectopic pregnancy, choriocarcinoma, and placenta accreta...

Using a decline in serum hCG between days 0-4 to predict ectopic pregnancy treatment success after single-dose methotrexate: A retrospective cohort study

M Skubisz, P Dutton, WC Duncan, AW Horne, S Tong

2013-02-01

Background: The current measure of treatment efficacy of single-dose methotrexate for ectopic pregnancy, is a fall in serum hCG of..

Corin, an enzyme with a putative role in spiral artery remodeling, is up-regulated in late secretory endometrium and first trimester decidua

TJ Kaitu'U-Lino, L Ye, L Tuohey, E Dimitriadis, J Bulmer, P Rogers, E Menkhorst, M Van Sinderen, JE Girling, N Hannan, S Tong

2013-01-01

Study Questio: NWhat is the nature of cellular Corin expression in human gestational tissues? Summary Answer: CORIN is expressed i..

MMP-15 is upregulated in preeclampsia, but does not cleave endoglin to produce soluble endoglin

TJ Kaitu'u-Lino, K Palmer, L Tuohey, L Ye, S Tong

2012-06-29

Preeclampsia is a major pregnancy complication, characterized by severe endothelial dysfunction, hypertension and maternal end-org..

Diagnostic accuracy of maternal serum macrophage inhibitory cytokine-1 and pregnancy-associated plasma protein-a at 6-10 weeks of gestation to predict miscarriage

S Tong, GL Ngian, JL Onwude, M Permezel, B Saglam, S Hay, JC Konje, TH Marczylo, G Fleming, SP Walker, M Lappas

2012-05-01

OBJECTIVE:: To determine whether serum macrophage inhibitory cytokine-1, pregnancy-associated plasma protein-A (PAPP-A), anandamid..

MMP-14 is expressed in preeclamptic placentas and mediates release of soluble endoglin

TJ Kaitu'U-Lino, KR Palmer, CL Whitehead, E Williams, M Lappas, S Tong

2012-03-01

Soluble endoglin is an anti-angiogenic protein that is released from the placenta and contributes to both maternal endothelial dys..

Serum concentrations of soluble flt-1 are decreased among women with a viable fetus and no symptoms of miscarriage destined for pregnancy loss

TJ Kaitu'u-Lino, CL Whitehead, GL Ngian, M Permezel, S Tong

2012-02-28

Miscarriage is the most common complication of pregnancy. Pre-clinical miscarriage has an estimated incidence of 30%, whilst clini..

Ultrasound Reference Chart Based on IVF Dates to Estimate Gestational Age at 6-9 weeks' Gestation.

Pavitra Delpachitra, Kirsten Palmer, Joseph Onwude, Simon Meagher, Luk Rombauts, Karen Waalwyk, Michael Bethune, Stephen Tong

2012-01-01

Accurate determination of gestational age underpins good obstetric care. We assessed the performance of six existing ultrasound re..

Is fetal growth restriction associated with a more severe maternal phenotype in the setting of early onset pre-eclampsia? a retrospective study

J Weiler, S Tong, KR Palmer

2011-11-03

Background: Both pre-eclampsia and fetal growth restriction are thought to result from abnormal placental implantation in early pr..

Measurement of mRNA transcripts of very high placental expression in maternal blood as biomarkers of preeclampsia

P Paiva, C Whitehead, B Saglam, K Palmer, S Tong

2011-11-01

Context: mRNA of placental origin in maternal blood shows potential as a clinical biomarker of obstetric diseases such as preeclam..

Placental expression of a novel primate-specific splice variant of sFlt-1 is upregulated in pregnancies complicated by severe early onset pre-eclampsia

CL Whitehead, KR Palmer, U Nilsson, Y Gao, B Saglam, M Lappas, S Tong

2011-09-01

sFlt-1 is increased in the placenta and serum of women with pre-eclampsia. A novel primate-specific splice variant has recently be..

Association between maternal serum cytokine profiles at 7-10 weeks' gestation and birthweight in small for gestational age infants

HM Georgiou, YS Thio, C Russell, M Permezel, YJ Heng, S Lee, S Tong

2011-01-01

Objective: The purpose of this study was to investigate whether birth of a small-for-gestational-age (SGA) baby (birthweight, <10t..

Severe early-onset preeclampsia is not associated with a change in placental catechol O-methyltransferase (COMT) expression

K Palmer, B Saglam, C Whitehead, O Stock, M Lappas, S Tong

2011-01-01

The genetic deletion of catechol O-methyltransferase (COMT) in mice produces a preeclampsia-like phenotype, with mice exhibiting h..

Rational design of immunostimulatory siRNAs

MP Gantier, S Tong, MA Behlke, AT Irving, M Lappas, UW Nilsson, E Latz, NAJ McMillan, BRG Williams

2010-01-01

Short-interfering RNAs (siRNAs) have engendered much enthusiasm for their ability to silence the expression of specific genes. How..